caa a22 4500 38809513X CHVBK 20180307125302.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S1092852900000821 doi S1092852900000821 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900000821 Neuroimaging Studies in Tourette Syndrome [Elektronische Daten] Tourette syndrome (TS) is a complex neurobehavioral disorder principally characterized by motor and vocal tics. However, features of obsessive-compulsive and attention-deficit/hyperactivity disorders are often present. The basal ganglia and associated brain structures have been implicated in the pathophysiology of TS, as well as in these related conditions. Specifically, it is believed that the neuroanatomically and functionally defined basal ganglia thalamocortical loops are involved in TS. These loops are composed of a sequence of connections originating in the cortex and passing in series through the striatum (caudate and putamen), globus pallidus, and thalamus before returning to the cortical areas of origin. This review concentrates on the neuroimaging findings in Ts, particularly as they relate to alterations in components of the basal ganglia thalamocortical circuits. These neuroimaging data suggest that the major abnormalities in TS involve striatal or cortical dysfunction, as well as dysfunction of dopaminergic systems that regulate basas ganglia neurotransmission. Copyright © Cambridge University Press 1999 Wright Christopher I. Peterson Bradley S. Rauch Scott L. CNS Spectrums Cambridge University Press 4/3(1999-03), 54-61 1092-8529 4:3<54 1999 4 CNS https://doi.org/10.1017/S1092852900000821 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900000821 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wright Christopher I. NATIONALLICENCE 700 1- Peterson Bradley S. NATIONALLICENCE 700 1- Rauch Scott L. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/3(1999-03), 54-61 1092-8529 4:3<54 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge