caa a22 4500 388095229 CHVBK 20180307125302.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S1092852900000808 doi S1092852900000808 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900000808 Alsobrook John P. The Genetics of Tourette Syndrome [Elektronische Daten] [John P. Alsobrook] The familial nature of Tourette syndrome (TS) was first described by Georges Gilles de la Tourette in 1885. Formal investigations of TS since the 1970s have consistently demonstrated an increased risk for TS among relatives of patients with TS. Family studies, twin studies, and segregation analyses all indicate that TS has significant genetic determinants. The mode of transmission, while mildly controversial, is generally believed to be due to at least one major locus inherited either as an autosomal dominant trait with reduced penetrance, or as a trait with intermediate inheritance in which some heterozygotic persons manifest the disorder. There is evidence for a TS spectrum of symptoms that includes chronic tics and obsessive-compulsive disorder. Systematic genome linkage studies of TS are progressing. To date, however, no significant linkage findings exist, although the search has included many neurologically relevant candidate genes. Copyright © Cambridge University Press 1999 CNS Spectrums Cambridge University Press 4/3(1999-03), 34-35,47-53 1092-8529 4:3<34 1999 4 CNS https://doi.org/10.1017/S1092852900000808 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900000808 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Alsobrook John P. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/3(1999-03), 34-35,47-53 1092-8529 4:3<34 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge