caa a22 4500 388095245 CHVBK 20180307125302.0 cr unu---uuuuu 161130e199901 xx s 000 0 eng 10.1017/S1092852900011202 doi S1092852900011202 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900011202 Becker Howard C. Alcohol Withdrawal: Neuroadaptation and Sensitization [Elektronische Daten] [Howard C. Becker] Repeated episodes of alcohol withdrawal may exacerbate the severity of future withdrawal occurrences. The progressive intensification of withdrawal symptoms may be manifested as a kindling-like mechanism. This sensitization process may reflect persistent perturbation in excitatory and inhibitory influences on brain function. Relapse is also thought to be affected by the kindling mechanism. Successive alcohol withdrawal experiences may also lead to neurologic damage and cognitive impairments. We review the research findings regarding the alcohol withdrawal kindling hypothesis and the implications of the kindling process on mechanisms of dependence, alcohol withdrawal treatment strategies, and the long-term repercussions of alcoholism. Copyright © Cambridge University Press 1999 CNS Spectrums Cambridge University Press 4/1(1999-01), 38-40,57-65 1092-8529 4:1<38 1999 4 CNS https://doi.org/10.1017/S1092852900011202 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900011202 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Becker Howard C. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/1(1999-01), 38-40,57-65 1092-8529 4:1<38 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge