caa a22 4500 388095539 CHVBK 20180307125303.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S109285290000119X doi S109285290000119X pii (NATIONALLICENCE)cambridge-10.1017/S109285290000119X Electrophysiology in Neuropsychiatric Research: A Network Perspective [Elektronische Daten] A growing number of anatomic and physiologic studies have shown that parallel sensory and motor information processing occurs in multiple cortical areas. These findings challenge the traditional model of brain processing, which states that the brain is a collection of physically discrete processing modules that pass information to each other by neuronal impulses in a stepwise manner. New concepts based on neural network models suggest that the brain is a dynamically shifting collection of interpenetrating, distributed, and transient neural networks. Neither of these models is necessarily mutually exclusive, but each gives different perspectives on the brain that might be complementary. Each model has its own research methodology, with functional magnetic resonance imaging supporting notions of modular processing, and electrophysiology (eg, electroencephalography) emphasizing the network model. These two technologies might be combined fruitfully in the near future to provide us with a better understanding of the brain. However, this common enterprise can succeed only when the inherent limitations and advantages of both models and technologies are known. After a general introduction about electrophysiology as a research tool and its relation to the network model, several practical examples are given on the generation of pathophysiologic models and disease classification, intermediate phenotyping for genetic investigations, and pharmacodynamic modeling. Finally, proposals are made about how to integrate electrophysiology and neuroimaging methods. Copyright © Cambridge University Press 1999 Winterer Georg Herrmann Werner M. Coppola Richard CNS Spectrums Cambridge University Press 4/8(1999-08), 17-29 1092-8529 4:8<17 1999 4 CNS https://doi.org/10.1017/S109285290000119X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S109285290000119X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Winterer Georg NATIONALLICENCE 700 1- Herrmann Werner M. NATIONALLICENCE 700 1- Coppola Richard NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/8(1999-08), 17-29 1092-8529 4:8<17 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge