caa a22 4500 388095571 CHVBK 20180307125303.0 cr unu---uuuuu 161130e199907 xx s 000 0 eng 10.1017/S1092852900012001 doi S1092852900012001 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900012001 Birnbaum Robert J. Neuroscience and Psychopharmacology into the Next Millennium [Elektronische Daten] [Robert J. Birnbaum] The end of the millennium provides an opportunity to review some of the common practices that were present in psychopharmacology during the 20th century. The author focuses on two approaches that have dominated research and guided the clinical application of psychopharmacologic therapeutics: the unitary clinically-based and single-lesion perspectives. The author expands upon these older formulations of neuropsychiatric disease pathogenesis and describes how the approach to psychopharmacologic research and therapeutics has changed in light of advances in the basic neurosciences. Relevant recent advances in the basic neurosciences that shed light on the pathophysiology of neuropsychiatric disease states and that guide psychopharmacologic practices are described. The use of atypical antipsychotic agents to treat schizophrenia is given as one example of the clinical applications of the approach to psychopharmacology in the next century. Copyright © Cambridge University Press 1999 CNS Spectrums Cambridge University Press 4/7(1999-07), 36-52 1092-8529 4:7<36 1999 4 CNS https://doi.org/10.1017/S1092852900012001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900012001 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Birnbaum Robert J. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/7(1999-07), 36-52 1092-8529 4:7<36 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge