caa a22 4500 388096101 CHVBK 20180307125304.0 cr unu---uuuuu 161130e199904 xx s 000 0 eng 10.1017/S1092852900011573 doi S1092852900011573 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900011573 Augmentation of Antidepressant Pharmacotherapy: A Preclinical Approach Using the Mouse Forced Swimming Test [Elektronische Daten] Until recently, several weeks of treatment were required in order to obtain a clinically significant antidepressant response using pharmacotherapy. The present study, using the mouse forced swimming test, investigated possible antidepressant augmentation strategies, together with the probable mechanisms involved in such potentiations. It is clear from this and other similar studies that it is possible to enhance the activity of antidepressant drugs with the addition of other compounds (ie, clonidine, quinine, glyburide, pindolol, or buspirone). These data indicate that direct/indirect manipulation of serotonergic receptor systems potentiates the effect antidepressant drugs (ie, selective serotonergic reuptake inhibitors) in the mouse forced swimming test, and thus establish this model as a reliable preclinical tool for the investigation of possible antidepressant augmentation strategies. It also appears that this model can be used as a method for identifying the mechanisms involved in such treatment strategies. Copyright © Cambridge University Press 1999 Redrobe John P. Bourin Michel CNS Spectrums Cambridge University Press 4/4(1999-04), 73-82 1092-8529 4:4<73 1999 4 CNS https://doi.org/10.1017/S1092852900011573 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900011573 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Redrobe John P. NATIONALLICENCE 700 1- Bourin Michel NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/4(1999-04), 73-82 1092-8529 4:4<73 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge