caa a22 4500 388096268 CHVBK 20180307125304.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S109285290001169X doi S109285290001169X pii (NATIONALLICENCE)cambridge-10.1017/S109285290001169X Genetic Anticipation in Portuguese Families With Bipolar Mood Disorder [Elektronische Daten] Genetic anticipation refers to an inheritance pattern within a pedigree showing a decrease in age of onset or an increase in disease severity or both in successive generations. This phenomenon has become the focus of important research in schizophrenia and bipolar mood disorder. The results to date have been controversial and far from conclusive. To attempt to resolve some of the earlier findings, we compared age at onset and disease severity between two generations in 24 Portuguese families ascertained for genetic linkage studies of bipolar mood disorder. There was a significant decrease in age of onset (P<. 00001) and increase in frequency of episodes (P<.0001)from the first to the second generation. This difference was significant under each of the four data-sampling schemes, one of which excluded probands. The second generation experienced onset 12.4 to 15.9 years earlier and illness 2.3 to 2.6 times more severe than did the first generation. We found no evidence for a specific effect in anticipation related to the transmitting parent's sex. Results of the present study, analyzed carefully for a variety of possible biases, suggest evidence for genetic anticipation in these Portuguese bipolar families. Copyright © Cambridge University Press 1999 Macedo Antonio Azevedo M. Helena Coelho Isabel Dourado Ana Valente Jose Pato Michele T. Soares Maria João Kennedy James L. Macciardi Fabio Pato Carlos N. CNS Spectrums Cambridge University Press 4/5(1999-05), 25-31 1092-8529 4:5<25 1999 4 CNS https://doi.org/10.1017/S109285290001169X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S109285290001169X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Macedo Antonio NATIONALLICENCE 700 1- Azevedo M. Helena NATIONALLICENCE 700 1- Coelho Isabel NATIONALLICENCE 700 1- Dourado Ana NATIONALLICENCE 700 1- Valente Jose NATIONALLICENCE 700 1- Pato Michele T. NATIONALLICENCE 700 1- Soares Maria João NATIONALLICENCE 700 1- Kennedy James L. NATIONALLICENCE 700 1- Macciardi Fabio NATIONALLICENCE 700 1- Pato Carlos N. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/5(1999-05), 25-31 1092-8529 4:5<25 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge