caa a22 4500 388096284 CHVBK 20180307125304.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S1092852900011688 doi S1092852900011688 pii (NATIONALLICENCE)cambridge-10.1017/S1092852900011688 Identification of a Highly Homogenous Population for Genetic Study of Psychiatric Disorders [Elektronische Daten] Many psychiatric disorders are influenced by genetic factors, but the genetic components of complex diseases may not follow clear inheritance patterns. Although the patients may share a common clinical phenotype, the cause of the syndrome may consist of a heterogeneous collection of both genetic and/or environmental components. One method to minimize genetic heterogeneity in studies of complex disorders is to select a very homogenous study population. The average number of families with the same last name, when corrected for population size, is an excellent marker for the degree of homogeneity. We used surname analysis to evaluate the homogeneity of the Portuguese population of Madeira, comparing it with previous data on the homogeneity of populations of mainland Portugal, the Azores, and both rural and urban US populations. The average number of families with the same last name corrected for population size was 33.84 in Madeira, 30.88 in the Azores, and 21.42 in Coimbra (mainland Portugal) compared with 1.13 in rural and 0.38 in urban United States. This surname analysis supports the premise that the Portuguese population is a highly homogenous population, with the highest homogeneity in Madeira and the Azores, making it a good study population for molecular genetic analyses. Copyright © Cambridge University Press 1999 Schindler Kim M. Torre Camille Dalla Bauer Amy Medeiros Helena Carvalho Celia Fernandes Luis Filipe Pato Michele T. Pato Carlos N. CNS Spectrums Cambridge University Press 4/5(1999-05), 22-24 1092-8529 4:5<22 1999 4 CNS https://doi.org/10.1017/S1092852900011688 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1092852900011688 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schindler Kim M. NATIONALLICENCE 700 1- Torre Camille Dalla NATIONALLICENCE 700 1- Bauer Amy NATIONALLICENCE 700 1- Medeiros Helena NATIONALLICENCE 700 1- Carvalho Celia NATIONALLICENCE 700 1- Fernandes Luis Filipe NATIONALLICENCE 700 1- Pato Michele T. NATIONALLICENCE 700 1- Pato Carlos N. NATIONALLICENCE 773 0- CNS Spectrums Cambridge University Press 4/5(1999-05), 22-24 1092-8529 4:5<22 1999 4 CNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge