caa a22 4500 388096438 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S002966519900083X doi S002966519900083X pii (NATIONALLICENCE)cambridge-10.1017/S002966519900083X Selectivity of fatty acids on lipid metabolism and gene expression [Elektronische Daten] Triacylglycerols represent the main form of storage for a wide spectrum of fatty acids. Their utilization first involves mobilization from adipose tissue through lipolysis. The release of individual fatty acids from adipose tissue is selective in vitro and in vivo in animal studies and also in human subjects. Generally, fatty acids are more readily mobilized from fat cells when they are short-chain and unsaturated. This selectivity could affect the storage of individual fatty acids in adipose tissue, and their subsequent supply to tissues. The nature of the dietary fats could affect lipid homeostasis and body fat deposition. Dietary fish oil influences adipose tissue development in a site-specific manner as a function of diet and feeding period. A diet high in n-3 polyunsaturated fatty acids (PUFA) results in a preferential partitioning of ingested energy towards oxidation at the expense of storage. Fatty acids are important mediators of gene expression in the liver. Indeed, genes encoding both glycolytic and lipogenic enzymes and key metabolic enzymes involved in fatty acid oxidation are regulated by dietary PUFA. White adipose tissue could also be a target for PUFA control of gene expression. The treatment of pre-adipose cells by fatty acids induces the expression of numerous genes that encode proteins involved in fatty acid metabolism. The mechanisms of PUFA-mediated repression of gene expression in adipocytes seem to be different, at least partly, from those described in liver. Tissue-specific and site-specific factors are possibly involved in the specific effect of PUFA on gene expression, although other mechanisms cannot be excluded. Copyright © The Nutrition Society 1999 Polyunsaturated fatty acids nationallicence Dietary obesity nationallicence Gene regulation nationallicence Raclot Thierry Centre d'Ecologie et Physiologie Energétiques, UPR 9010 CNRS, associé à l'Université; Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France Oudart Hugues Centre d'Ecologie et Physiologie Energétiques, UPR 9010 CNRS, associé à l'Université; Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 633-646 0029-6651 58:3<633 1999 58 PNS https://doi.org/10.1017/S002966519900083X text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S002966519900083X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raclot Thierry Centre d'Ecologie et Physiologie Energétiques, UPR 9010 CNRS, associé à l'Université; Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France NATIONALLICENCE 700 1- Oudart Hugues Centre d'Ecologie et Physiologie Energétiques, UPR 9010 CNRS, associé à l'Université; Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 633-646 0029-6651 58:3<633 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge