caa a22 4500 388096543 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S002966519900097X doi S002966519900097X pii (NATIONALLICENCE)cambridge-10.1017/S002966519900097X Macallan Derek C. Division of Infectious Diseases, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK Nutrition and immune function in human immunodeficiency virus infection [Elektronische Daten] [Derek C. Macallan] The triad of human immunodeficiency virus (HIV) infection, nutritional status and immune function are intimately related, each factor having effects on the others. The dominant effect in this three-way relationship is the effect of HIV infection on nutritional status, an effect which, until the advent of potent anti-retroviral drugs, has been manifest primarily as wasting. Recently, more complex metabolic abnormalities have become apparent, particularly fat redistribution syndromes, hyperlipidaemia and hypercholesterolaemia. For the converse effect, the effect of nutritional state on HIV disease progression, there is good evidence that clinical outcome is poorer in individuals with compromised nutrition. However, the beneficial effects of nutritional support have been more difficult to demonstrate. For macronutrients, effective macronutrient supply improves survival in severely-malnourished individuals and may have beneficial effects in less-severely-affected individuals. Micronutrient deficiencies appear to be involved in modifying clinical HIV disease and may also be associated with enhanced mother-to-child transmission of virus, particularly in developing countries. Intervention trials in this setting are currently under way. In conclusion, the interaction of HIV infection and nutrition is of great importance not just because of the major impact that HIV infection has on nutritional state, but also because strategies to improve nutritional status, both quantitatively and qualitatively, may have a beneficial effect on the clinical and immunological course of the disease. Copyright © The Nutrition Society 1999 HIV infection nationallicence AIDS nationallicence Nutritional status nationallicence Wasting nationallicence Micronutrients nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 743-748 0029-6651 58:3<743 1999 58 PNS https://doi.org/10.1017/S002966519900097X text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S002966519900097X text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Macallan Derek C. Division of Infectious Diseases, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 743-748 0029-6651 58:3<743 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge