caa a22 4500 388096624 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S0029665199000932 doi S0029665199000932 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000932 Hughes David A. Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK Effects of carotenoids on human immune function [Elektronische Daten] [David A. Hughes] Many epidemiological studies have shown an association between diets rich in carotenoids and a reduced incidence of many forms of cancer, and it has been suggested that the antioxidant properties of these compounds are a causative factor. Attention has focused on the potential role of one specific carotenoid, β-carotene, in preventing cancer, and numerous publications have described in vitro experiments and animal studies which suggest that not only can this carotenoid protect against the development of cancer, but also several other chronic diseases. Since the immune system plays a major role in cancer prevention, it has been suggested that β-carotene may enhance immune cell function. Several human trials, using dietary β-carotene supplementation with a wide range of intakes, have been undertaken to address this hypothesis. The general conclusion of these studies is that this compound can enhance cell-mediated immune responses, particularly in the elderly. The present article will review some of these human studies and, hopefully, complement the reviews of other authors associated with the present symposium, some of whom will also describe work in this area. Potential mechanisms for the effects of carotenoids on immune function will also be reviewed. Finally, possible reasons for the failure of three major prospective studies to demonstrate a beneficial effect of β-carotene supplementation on lung cancer risk will be discussed. Copyright © The Nutrition Society 1999 Carotenoids nationallicence Immune function nationallicence -Carotene nationallicence Monocyte nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 713-718 0029-6651 58:3<713 1999 58 PNS https://doi.org/10.1017/S0029665199000932 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000932 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hughes David A. Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 713-718 0029-6651 58:3<713 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge