caa a22 4500 388096632 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S0029665199000890 doi S0029665199000890 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000890 Chandra R. K. Department of Pediatrics and Medicine, Division of Immunology, Memorial University of Newfoundland, St John's Newfoundland AIA IR8, Canada and Division of Nutrition, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA Nutrition and immunology: from the clinic to cellular biology and back again [Elektronische Daten] [R. K. Chandra] Diet and immunity have been known to be linked to each other for centuries. In the last 30 years systematic studies have confirmed that nutrient deficiencies impair immune response and lead to frequent severe infections resulting in increased mortality, especially in children. Protein-energy malnutrition results in reduced number and functions of T-cells, phagocytic cells and secretory immunoglobulin A antibody response. In addition, levels of many complement components are reduced. Similar findings have been reported for moderate deficiencies of individual nutrients such as trace minerals and vitamins, particularly Zn, Fe, Se, vitamins A, B6, C and E. For example, Zn deficiency is associated with profound impairment of cell-mediated immunity such as lymphocyte stimulation response, decreased CD4+:CD8+ cells, and decreased chemotaxis of phagocytes. In addition, the level of thymulin, which is a Zn-dependent hormone, is markedly decreased. The use of nutrient supplements, singly or in combination, stimulates immune response and may result in fewer infections, particularly in the elderly, low-birth-weight infants and malnourished critically-ill patients in hospitals. The interactions between nutrition and the immune system are of clinical, practical and public health importance. Copyright © The Nutrition Society 1999 Trace elements nationallicence Ageing nationallicence Low-birth-weight infants nationallicence Immune responses nationallicence Infection nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 681-683 0029-6651 58:3<681 1999 58 PNS https://doi.org/10.1017/S0029665199000890 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000890 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Chandra R. K. Department of Pediatrics and Medicine, Division of Immunology, Memorial University of Newfoundland, St John's Newfoundland AIA IR8, Canada and Division of Nutrition, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 681-683 0029-6651 58:3<681 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge