caa a22 4500 388096667 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S0029665199000725 doi S0029665199000725 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000725 Validity of animal models for the cholesterol-raising effects of coffee diterpenes in human subjects [Elektronische Daten] Cafestol and kahweol, coffee lipids present in unfiltered coffee brews, potently increase LDL-cholesterol concentration in human subjects. We searched for an animal species in which cafestol similarly increases LDL-cholesterol. Such an animal model could be used subsequently as a model to study the mechanism of action of cafestol and kahweol. Cafestol and kahweol increased serum lipids in African green monkeys (Cercopithecus aethiops), cebus (Cebus apella) and rhesus (Macaca mulatta) monkeys, hamsters, rats and gerbils differently from the increase in human subjects. In African green monkeys, the rise in total cholesterol was less pronounced than that in human subjects. In addition, the increase in total cholesterol was predominantly due to a rise in HDL-cholesterol rather than LDL-cholesterol. Thus, the rise in plasma lipids might illustrate the mechanism in these monkeys rather than the mechanism in human subjects. In other animal species, cafestol and kahweol did not raise cholesterol consistently. The variability in effects on serum lipids could not be explained by the mode of administration or dose of diterpenes, nor by the amount of cholesterol in the diet. In conclusion, we did not find an animal model in which cafestol and kahweol elevate plasma lipoproteins to the same extent as in human subjects. For the time being, therefore, studies on the mechanism of action should be done preferably in human subjects. Copyright © The Nutrition Society 1999 Animal models nationallicence Serum lipoproteins nationallicence Coffee nationallicence Cafestol and kahweol nationallicence de Roos Baukje Division of Human Nutrition & Epidemiology, Wageningen Agricultural University, POB 8129, 6700 EV Wageningen, The Netherlands Sawyer Janet K. Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA Katan Martijn B. Division of Human Nutrition & Epidemiology, Wageningen Agricultural University, POB 8129, 6700 EV Wageningen, The Netherlands Rudel Lawrence L. Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 551-557 0029-6651 58:3<551 1999 58 PNS https://doi.org/10.1017/S0029665199000725 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000725 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Roos Baukje Division of Human Nutrition & Epidemiology, Wageningen Agricultural University, POB 8129, 6700 EV Wageningen, The Netherlands NATIONALLICENCE 700 1- Sawyer Janet K. Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA NATIONALLICENCE 700 1- Katan Martijn B. Division of Human Nutrition & Epidemiology, Wageningen Agricultural University, POB 8129, 6700 EV Wageningen, The Netherlands NATIONALLICENCE 700 1- Rudel Lawrence L. Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 551-557 0029-6651 58:3<551 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge