caa a22 4500 388096683 CHVBK 20180307125305.0 cr unu---uuuuu 161130e199908 xx s 000 0 eng 10.1017/S0029665199000816 doi S0029665199000816 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000816 Ferré P. U465 INSERM, Centre Biomédical des Cordeliers, 15 rue de L′Ecole de Médecine, 75270 Paris Cedex 06, France Regulation of gene expression by glucose [Elektronische Daten] [P. Ferré] Fatty acid synthase (EC 2.3.1.85) is an enzyme involved in the lipogenic pathway allowing fatty acid synthesis from glucose. Glucose up-regulates the transcription of the fatty acid synthase gene in both adipocytes and hepatocytes, with insulin having only an indirect role. The signal metabolite could be glucose-6-phosphate rather than glucose itself. The glucose response element of the fatty acid synthase gene has not yet been precisely identified, although a −2 kb region of the fatty acid synthase promoter is sufficient to confer nutritional responsiveness to a reporter gene. ADD1/SREBP1, a b-HLH-LZ transcription factor belonging to the sterol regulatory element-binding protein family might be involved in the transduction of the glucose effect. Finally, the stimulatory effect of glucose on the expression of the fatty acid synthase gene is inhibited by the activation of AMP-activated protein kinase. Interestingly enough, AMP-activated protein kinase is structurally and functionally related to the yeast SNF1 protein kinase complex which is essential for the transcriptional activation of glucose-repressed genes in Saccharomyces cerevisiae. Copyright © The Nutrition Society 1999 Glucose nationallicence Gene regulation nationallicence Fatty acid synthase nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 621-623 0029-6651 58:3<621 1999 58 PNS https://doi.org/10.1017/S0029665199000816 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000816 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ferré P. U465 INSERM, Centre Biomédical des Cordeliers, 15 rue de L′Ecole de Médecine, 75270 Paris Cedex 06, France NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/3(1999-08), 621-623 0029-6651 58:3<621 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge