caa a22 4500 38809673X CHVBK 20180307125305.0 cr unu---uuuuu 161130e199902 xx s 000 0 eng 10.1079/PNS19990025 doi S0029665199000270 pii (NATIONALLICENCE)cambridge-10.1079/PNS19990025 Phyto-oestrogens: A potential role in the prevention of CHD? [Elektronische Daten] CHD is a major cause of morbidity and mortality in women. The incidence of CHD in premenopausal women is low but increases substantially after the menopause, and this difference suggests that endogenous oestrogens are cardioprotective. Observational prospective studies have consistently shown that exogenous oestrogens also lower CHD risk. The biological mechanisms by which endogenous and exogenous oestrogens exert their protective effect are multifactorial, affecting lipids, carbohydrate metabolism, body fat distribution and blood pressure. The prevention of CHD with oestrogen therapy is therefore aimed both at correction of the traditional risk factors and at direct control of vessel structure and function. The wide international variation in rates of CHD together with the lower mortality in sub-groups of the population suggests that a considerable proportion of CHD may be prevented by dietary modification. Since phyto-oestrogens are structually similar to oestrogen, they have the potential to mimic its effects in vivo. The hypocholesterolaemic effects of soyabean protein (rich in phyto-oestrogen precursors) are well established, but the underlying mechanism and atherogenic potential of these changes are unknown. One isoflavone, genistein, has been shown in vitro to exert effects which may slow the development of atherosclerotic disease. However, further studies are required to determine the dose-related changes induced by phyto-oestrogens on serum lipoproteins, haemostasis and vascular function. Copyright © The Nutrition Society 1999 Phyto-oestrogens nationallicence Oestrogens nationallicence Lignans nationallicence Soyabean nationallicence CHD nationallicence Cassidy Aedin Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK Griffin Bruce Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK Proceedings of the Nutrition Society Cambridge University Press 58/1(1999-02), 193-199 0029-6651 58:1<193 1999 58 PNS https://doi.org/10.1079/PNS19990025 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1079/PNS19990025 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cassidy Aedin Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK NATIONALLICENCE 700 1- Griffin Bruce Centre for Nutrition and Food Safety, University of Surrey, Guildford, GU2 5XH, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/1(1999-02), 193-199 0029-6651 58:1<193 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge