caa a22 4500 388096934 CHVBK 20180307125306.0 cr unu---uuuuu 161130e199902 xx s 000 0 eng 10.1079/PNS19990010 doi S0029665199000129 pii (NATIONALLICENCE)cambridge-10.1079/PNS19990010 The influence of the maternal uterine immune response on placentation in human subjects [Elektronische Daten] The immunological relationship beween the mammalian fetus and its mother during pregnancy has been considered similar to that between a transplanted allograft and its recipient ever since Medawar (1953) first proposed the concept of the ‘fetus as an allograft' in the early 1950s. Based on this analogy, it has been assumed that implantation of the fetal placenta in the uterus would be controlled similarly by a maternal immune response mediated by T-cells recognizing paternally-derived alloantigens expressed by the placenta. Surprisingly, recent evidence suggests that implantation might involve predominantly a novel allogeneic recognition system based on natural killer cells rather than T-cells (Loke & King, 1995). The cellular and molecular basis of this local immune interaction between the fetal placenta and maternal uterus is now the focus of intense research interest. Since aberrant implantation can cause a variety of clinical problems, including miscarriage, intrauterine growth retardation and pre-eclampsia, an understanding of the immunological mechanism by which this process is controlled could lead to the development of regimens to improve fetal growth and development. Copyright © The Nutrition Society 1999 Placenta nationallicence Trophoblast nationallicence Natural killer cells nationallicence Immunology nationallicence King Ashley Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK Loke Y. W. Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK Proceedings of the Nutrition Society Cambridge University Press 58/1(1999-02), 69-73 0029-6651 58:1<69 1999 58 PNS https://doi.org/10.1079/PNS19990010 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1079/PNS19990010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- King Ashley Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK NATIONALLICENCE 700 1- Loke Y. W. Research Group in Human Reproductive Immunobiology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/1(1999-02), 69-73 0029-6651 58:1<69 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge