caa a22 4500 388097035 CHVBK 20180307125306.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S0029665199001354 doi S0029665199001354 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199001354 van der Pols Jolieke C. Medical Research Council Human Nutrition Research, Milton Road, Cambridge CB4 IXJ, UK A possible role for vitamin C in age-related cataract [Elektronische Daten] [Jolieke C. van der Pols] While many experimental studies have shown a protective effect of vitamin C in age-related cataract, other studies have revealed contrasting roles for this nutrient. Oxidative damage in the lens can be prevented by vitamin C. However, a pro-oxidant effect of vitamin C through H2O2 generation has been suggested. Vitamin C has also been shown to play a role in protein glycation, which is observed in cataract formation. A protective effect of dietary energy restriction appears to be inversely related to plasma vitamin C levels in rodents. Moreover, conclusions from human epidemiological and intervention studies are not uniform. The available evidence suggests that maintenance of sufficient plasma vitamin C is needed to prevent oxidative damage in the lens. More research will be needed in order to confirm the relative importance of the different roles of vitamin C in the eye lens. Copyright © The Nutrition Society 1999 Vitamin C nationallicence Cataract nationallicence Antioxidants nationallicence Old age nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 295-301 0029-6651 58:2<295 1999 58 PNS https://doi.org/10.1017/S0029665199001354 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199001354 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- van der Pols Jolieke C. Medical Research Council Human Nutrition Research, Milton Road, Cambridge CB4 IXJ, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 295-301 0029-6651 58:2<295 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge