caa a22 4500 388097086 CHVBK 20180307125306.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S0029665199000634 doi S0029665199000634 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000634 Cook James D. Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA Defining optimal body iron [Elektronische Daten] [James D. Cook] The major liabilities of Fe lack include defects in psychomotor development in infants, impaired educational performance in schoolchildren, increased perinatal morbidity, and impaired work capacity. Few if any of the relevant investigations have demonstrated these abnormalities in the absence of anaemia. Consequently, adequate Fe nutrition can be defined as a normal haemoglobin concentration. On the other hand, optimal Fe nutrition should be regarded as sufficient body Fe to avoid any limitation in tissue Fe supply, termed Fe-deficient erythropoiesis. A variety of laboratory measurements have been used to identify this milder form of Fe deficiency, including serum ferritin, transferrin saturation, erythrocyte protoporphyrin, mean corpuscular volume, and more recently the concentration of the soluble fragment of transferrin receptor in serum. Recent studies indicate that the serum transferrin receptor is the preferred measurement, because enhanced synthesis of the transferrin receptor represent the initial cellular response to a declining Fe supply. Moreover, unlike other methods, it is not affected by chronic inflammation or infection which are often confused with Fe deficiency. In an otherwise normal healthy population the transferrin receptor: ferritin value provides a useful quantitative index of body Fe over a wide spectrum of Fe status, ranging from Fe repletion to Fe-deficiency anaemia. It is concluded that optimal Fe nutrition is best defined as a normal haemoglobin, serum ferritin and transferrin receptor concentration. Copyright © The Nutrition Society 1999 Iron deficiency nationallicence Serum transferrin receptor nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 489-495 0029-6651 58:2<489 1999 58 PNS https://doi.org/10.1017/S0029665199000634 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000634 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Cook James D. Department of Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 489-495 0029-6651 58:2<489 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge