caa a22 4500 388097205 CHVBK 20180307125307.0 cr unu---uuuuu 161130e199905 xx s 000 0 eng 10.1017/S0029665199000385 doi S0029665199000385 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199000385 Childhood leukaemia: a model of pre-obesity [Elektronische Daten] The prevalence of obesity in children, as in adults, is increasing dramatically. The extent to which this is due to reduced energy expenditure, increased energy intake, or both, is unclear at present. This in part reflects the limitations of existing models of the pre-obese state. In childhood acute lymphoblastic leukaemia (ALL), patients typically gain weight excessively during and after 2 years of therapy, and are at high risk of becoming obese. Previous studies have failed to identify the cause of obesity in these patients. We have tested the hypothesis that excess weight gain in ALL is due to reduced total energy expenditure (TEE), measured using the doubly-labelled water method, and have identified risk factors for excess weight gain in ALL. Pre-obese children with ALL in the dynamic phase of weight gain are less physically active than their peers, with a reduced TEE of approximately 1.2 (95 % CI 0.2, 2.2) MJ/d. While other factors might contribute to excess weight gain, lifestyle (i.e. reduced habitual physical activity) plays a central role in ALL. Several considerations suggest that ALL might be a useful model of the pre-obese state: lifestyle is critical to development of obesity in ALL; ALL is relatively common; approximately 70 % of patients survive; patients are readily accessible during the 2 years of therapy and beyond. Copyright © The Nutrition Society 1999 Obesity nationallicence Physical activity nationallicence Doubly-labelled water nationallicence Energy expenditure nationallicence Ventham J. C. Department of Human Nutrition, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ, UK Reilly J. J. Department of Human Nutrition, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ, UK Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 277-281 0029-6651 58:2<277 1999 58 PNS https://doi.org/10.1017/S0029665199000385 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199000385 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ventham J. C. Department of Human Nutrition, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ, UK NATIONALLICENCE 700 1- Reilly J. J. Department of Human Nutrition, University of Glasgow, Yorkhill Hospital, Glasgow G3 8SJ, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/2(1999-05), 277-281 0029-6651 58:2<277 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge