caa a22 4500 388097353 CHVBK 20180307125307.0 cr unu---uuuuu 161130e199911 xx s 000 0 eng 10.1017/S0029665199001214 doi S0029665199001214 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199001214 Arner Peter Karolinska Institute, Department of Medicine, Huddinge Hospital, S-141 86 Huddinge, Sweden Microdialysis: use in human exercise studies [Elektronische Daten] [Peter Arner] Microdialysis has been used for 25 years to study brain function in vivo. Recently, it has been developed for investigations on peripheral tissues. A microdialysis catheter is an artificial blood vessel system which can be placed in the extracellular space of various tissues such as adipose tissue and skeletal muscle in order to examine these tissues in situ. Molecules are collected from the tissue by the device and their true interstitial concentration can be estimated. Metabolically-active molecules can be delivered to the interstitial space through the microdialysis probe and their action on the tissue can be investigated locally without producing generalized effects. It is also possible to study local tissue blood flow with microdialysis by adding a flow marker (usually ethanol) to the microdialysis solvent. The microdialysis technique is particularly useful for studies of small and water-soluble molecules. A number of important observations on the in vivo regulation of lipolysis, carbohydrate metabolism and blood flow in human skeletal muscle and adipose tissue have been made recently using microdialysis. The Nutrition Society Microdialysis nationallicence Skeletal muscle nationallicence Adipose tissue nationallicence Blood flow nationallicence Exercise nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 913-917 0029-6651 58:4<913 1999 58 PNS https://doi.org/10.1017/S0029665199001214 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199001214 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Arner Peter Karolinska Institute, Department of Medicine, Huddinge Hospital, S-141 86 Huddinge, Sweden NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 913-917 0029-6651 58:4<913 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge