caa a22 4500 388097418 CHVBK 20180307125307.0 cr unu---uuuuu 161130e199911 xx s 000 0 eng 10.1017/S0029665199001172 doi S0029665199001172 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199001172 Macdonald I. A. School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK Arterio-venous differences to study macronutrient metabolism: introduction and overview [Elektronische Daten] [I. A. Macdonald] The arterio-venous difference technique is now well established in the study of organ and tissue metabolism. This technique requires samples to be obtained of the arterial blood supplying and the venous drainage from a tissue, together with a measurement of the blood flow through the tissue. The technique is most appropriate when the arterial concentration and tissue metabolism of a substance are constant, and when the blood flow is stable. If these criteria are not satisfied, care is needed in the interpretation of the results obtained. It should be recognized that the arterio-venous difference technique only measures the net exchange of a substance with the tissue, and that tracers are needed if unidirectional flux needs to be estimated. The other factors which must be borne in mind when intending to use this technique are the transit times of blood and the substance of interest through a tissue, the volume of distribution of the substance in the tissue, and the possibility that the venous samples obtained are derived from a mixture of different tissues. The Nutrition Society Arterio-venous difference nationallicence Tissue metabolism nationallicence Fick Principle nationallicence Arterialization nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 871-875 0029-6651 58:4<871 1999 58 PNS https://doi.org/10.1017/S0029665199001172 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199001172 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Macdonald I. A. School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 871-875 0029-6651 58:4<871 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge