caa a22 4500 388097442 CHVBK 20180307125307.0 cr unu---uuuuu 161130e199911 xx s 000 0 eng 10.1017/S0029665199001160 doi S0029665199001160 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199001160 Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle [Elektronische Daten] 31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusing on human applications, but with some illustrative examples from studies on transgenic mice. Topics which are described in the present paper are the information content of the 31P magnetic resonance spectrum of skeletal muscle, some practical issues in the performance of this MRS methodology, related muscle biochemistry and the validity of interpreting results in terms of biochemical processes, the possibility of investigating reaction kinetics in vivo and some indications for fibre-type heterogeneity as seen in spectra obtained during exercise. The Nutrition Society 31P magnetic resonance spectroscopy nationallicence Skeletal muscle nationallicence High-energy phosphates nationallicence Energy metabolism nationallicence Exercise nationallicence Heerschap A. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands Houtman C. Department of Neurology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands in 't Zandt H. J. A. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands van den Bergh A. J. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands Wieringa B. Department of Cell Biology and Histology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 861-870 0029-6651 58:4<861 1999 58 PNS https://doi.org/10.1017/S0029665199001160 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199001160 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heerschap A. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 700 1- Houtman C. Department of Neurology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 700 1- in 't Zandt H. J. A. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 700 1- van den Bergh A. J. Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 700 1- Wieringa B. Department of Cell Biology and Histology, Faculty of Medical Sciences, University of Nijmegen, 6500 HB Nijmegen, The Netherlands NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 861-870 0029-6651 58:4<861 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge