caa a22 4500 388097663 CHVBK 20180307125308.0 cr unu---uuuuu 161130e199911 xx s 000 0 eng 10.1017/S0029665199001238 doi S0029665199001238 pii (NATIONALLICENCE)cambridge-10.1017/S0029665199001238 Bangsbo J. Copenhagen Muscle Research Centre, The August Krogh Institute, LHF, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark Vasoactive substances in the interstitium of contracting skeletal muscle examined by microdialysis [Elektronische Daten] [J. Bangsbo] In the study of the regulation of skeletal muscle blood flow during exercise it is useful to obtain information regarding the concentrations of vasoactive substances in the muscle interstitium, a site where the compounds act on the vascular and skeletal muscle cells. The microdialysis technique is a useful tool for measuring interstitial substances in the muscle at rest and during exercise in human subjects, and the technique can also be used to study the effect of both systemic and local interventions in a specific area of an exercising muscle. Probe recovery, which represents the relative amount of a substance that is diffusing to the dialysis membrane, changes from rest to exercise and can be determined by the internal-standard technique which allows for a relatively high time resolution (min). Furthermore, the use of electrodes at the microdialysis outlet makes it possible to perform continuous measurements of interstitial substances. The present review gives examples of how the microdialysis technique has been applied to study potentially important vasodilators such as adenosine, NO and K+ in human skeletal muscles and highlights areas for future research to establish the functional importance of these compounds. The Nutrition Society Adenosine nationallicence Nitric oxide nationallicence Potassium nationallicence pH nationallicence Exercise nationallicence Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 925-933 0029-6651 58:4<925 1999 58 PNS https://doi.org/10.1017/S0029665199001238 text/html Onlinezugriff via DOI 1 conference jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0029665199001238 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bangsbo J. Copenhagen Muscle Research Centre, The August Krogh Institute, LHF, Universitetsparken 13, DK-2100 Copenhagen Ø, Denmark NATIONALLICENCE 773 0- Proceedings of the Nutrition Society Cambridge University Press 58/4(1999-11), 925-933 0029-6651 58:4<925 1999 58 PNS CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge