caa a22 4500 388110856 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199909 xx s 000 0 eng 10.1017/S0924270800036061 doi S0924270800036061 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036061 Acoustic startle responses of rats with cerebral developmental abnormalities: implications for schizophrenia [Elektronische Daten] Prepuls-inhibitie en habituatie in ratten met cerebrate ontwik-kelingsstoornissen; implicaties voor schizofrenie Mounting evidence suggests involvement of prenatal factors in the pathogenesis of schizophrenia. The objective of the present study was to provide evidence for the hypothesis on schizophrenia that abnormal fetal brain development leads to impaired sensorimotor gating of acoustic startle stimuli. To this purpose, pregnant rats were treated with methylazoxymethanol acetate on one of four subsequent days of gestation, from E9 to E12. These procedures inhibit early stages of cortical proliferation in the foetuses, resulting in adult brain abnormalities that were mainly found in the entorhinal region. At the adult age, habituation andprepulse inhibition (PPI) of startle responses to acoustic stimuli were investigated. Our results show impaired habituation and PPI in rats treated at embryonic days 10 and 11. It is concluded that sensorimotor gating deficits can result from a developmental abnormality involving the entorhinal region, supporting the hypothesis that similar deficits, often observed in schizophrenic subjects, may be the result of entorhinal cortex dysfunction. Copyright © Cambridge University Press 1999 Acoustic startle nationallicence animal model nationallicence development nationallicence habituation nationallicence prepulse inhibition nationallicence schizophrenia nationallicence Sleutelwoorden:Akoestische schrikreflex nationallicence diermodel nationallicence habituatie nationallicence ontwikkeling nationallicence prepuls-inhibitie nationallicence Talamini L.M. Dept. Psychonomics, University of Amsterdam Ellenbroek B. Dept. Biological Psychiatry, University Hospital of Groningen Koch T. Dept. Psychonomics, University of Amsterdam Korf J. Dept. Psychonomics, University of Amsterdam Acta Neuropsychiatrica Cambridge University Press 11/3(1999-09), 110-113 0924-2708 11:3<110 1999 11 NEU https://doi.org/10.1017/S0924270800036061 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036061 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Talamini L.M. Dept. Psychonomics, University of Amsterdam NATIONALLICENCE 700 1- Ellenbroek B. Dept. Biological Psychiatry, University Hospital of Groningen NATIONALLICENCE 700 1- Koch T. Dept. Psychonomics, University of Amsterdam NATIONALLICENCE 700 1- Korf J. Dept. Psychonomics, University of Amsterdam NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/3(1999-09), 110-113 0924-2708 11:3<110 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge