caa a22 4500 388110864 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199909 xx s 000 0 eng 10.1017/S0924270800036024 doi S0924270800036024 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036024 Hoes M.J.A.J.M. Recent antipsychotics in the treatment of psychoses [Elektronische Daten] [M.J.A.J.M. Hoes] Antipsychotic drugs are effective in psychoses, whatever the etiology of the disorder. The positive symptoms tend to respond more readily. The need for developing new drugs arises from the refractoriness of the negative symptoms, the 10-25% of the patients that are treatment-resistant and the problems of short-, and long-term extrapyramidal side-effects. Thus far, six drugs, differing from the classical antipsychotics, have been licensedfor use: olanzepine, risperidone and quetiapine; the longest registration exists for sulpiride and clozapine while the most recent one is for amisulpride. This review starts with a brief introduction to symptomatology, and takes differences with the classical drugs in pharmacology, pharmacokinetics, clinical aspects and side-effects into consideration. Clozapine, risperidone and sulpiride may be considered for clinical use in refractory patients; these three, olanzapine and amisulpride when extrapyramidal side-effects cause a clinical problem. Amisulpride and sulpiride have a dual therapeutic acion: On negative symptoms at low dose, on positive symptomen at high doses. Copyright © Cambridge University Press 1999 Antipsychotic nationallicence atypical antipsychotic nationallicence psychosis nationallicence management nationallicence amisulpride nationallicence clozapine nationallicence olanzapine nationallicence quetiapine nationallicence risperidone nationallicence sulpiride nationallicence Antipsychoticum nationallicence atypisch antipsychoticum nationallicence psychose behandeling nationallicence amisulpride nationallicence clozapine nationallicence olanzapine nationallicence quetiapine nationallicence risperidone nationallicence sulpiride nationallicence Acta Neuropsychiatrica Cambridge University Press 11/3(1999-09), 85-92 0924-2708 11:3<85 1999 11 NEU https://doi.org/10.1017/S0924270800036024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036024 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hoes M.J.A.J.M. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/3(1999-09), 85-92 0924-2708 11:3<85 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge