caa a22 4500 388111070 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199912 xx s 000 0 eng 10.1017/S0924270800035869 doi S0924270800035869 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800035869 Cytokines in de obsessief compulsieve stoornis en in anorexia nervosa: een overzicht [Elektronische Daten] The alterations in the inflammatory response system (IRS) appear to be quite different between OCD and anorexia nervosa and are also different from the changes observed in major depression. In anorexia nervosa, there is some evidence for increased production of monocytic cytokines, i.e. tumor necrosis factor-α (TNFα) and interleukin-6 (IL-6), and decreased production of Th-1 like cytokines, i.e. IL-2 and IFNγ. In the same patients there are also signs of immunosuppression, e.g. lowered numbers of CD4 and CD8 T cells and increased production of transforming growth factor-beta (TGFβ). The increased production of monocytic cytokines may be the consequence of the hyponutritional status of those patients. The diminished production of the Th-1 like cytokines may be the consequence of at least four different factors: 1) the deficiency in nutritional factors; 2) neuroendocrine disorders, such as increased Cortisol production; 3) the increased TGFβ production; and 4) lower serum dipeptidyl peptidase activity. In OCD no consistent or specific alterations in the IRS are observed. There is no evidence that IRS activation may play a role in the pathophysiology of OCD and anorexia nervosa. Copyright © Cambridge University Press 1999 cytokines nationallicence anorexia nervosa nationallicence OCD nationallicence van West D. Clinical Research Center for Mental Health (CRCMH), Antwerp, Belgium Maes M. Istituto Fatebenefratelli, Brescia, Italy; Department of Psychiatry, Vanderbilt University, Nashville, USA, Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, the Netherlands. Acta Neuropsychiatrica Cambridge University Press 11/4(1999-12), 125-129 0924-2708 11:4<125 1999 11 NEU https://doi.org/10.1017/S0924270800035869 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800035869 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van West D. Clinical Research Center for Mental Health (CRCMH), Antwerp, Belgium NATIONALLICENCE 700 1- Maes M. Istituto Fatebenefratelli, Brescia, Italy; Department of Psychiatry, Vanderbilt University, Nashville, USA, Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, the Netherlands NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/4(1999-12), 125-129 0924-2708 11:4<125 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge