caa a22 4500 388111097 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S0924270800036309 doi S0924270800036309 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036309 Therapeutic drug monitoring [Elektronische Daten] Therapeutische drug monitoring The cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2. Knowledge about the involvement of these enzymes and biotransformation processes is mandatory because of the individual variability in their metabolic capacity. Regular measurement of plasmaconcentrations of (psycho)pharmacological compounds is therefore essential. In addition, the potential value of pheno- and/or genotyping has to be investigated. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Cytochrome P450 iso-enzymes nationallicence genetic polymorphism nationallicence bloodplasma concentrations nationallicence Cytochoom P450 enzymen nationallicence genetisch polymorphisme nationallicence bloedplasmaconcentraties nationallicence Noten J.B.G.M. Ziekenhuisapotheker, Farmaceutisch Laboratorium, Stichting, ZALV, Venray Verhoeven W.M.A. Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray Tuinier S. Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray Touw D. Ziekenhuisapotheker, Apotheek Academisch Ziekenhuis, Vrije Universiteit, Amsterdam Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 15-16 0924-2708 11:1<15 1999 11 NEU https://doi.org/10.1017/S0924270800036309 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036309 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noten J.B.G.M. Ziekenhuisapotheker, Farmaceutisch Laboratorium, Stichting, ZALV, Venray NATIONALLICENCE 700 1- Verhoeven W.M.A. Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray NATIONALLICENCE 700 1- Tuinier S. Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray NATIONALLICENCE 700 1- Touw D. Ziekenhuisapotheker, Apotheek Academisch Ziekenhuis, Vrije Universiteit, Amsterdam NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 15-16 0924-2708 11:1<15 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge