caa a22 4500 388111194 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S0924270800036292 doi S0924270800036292 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036292 de Kloet E.R. Neurobiology of adaptation disorders [Elektronische Daten] [E.R. de Kloet] Neurobiologie van adaptatiestoornissen A fundamental issue in the neurobiology of adaptation disorders is how the hormones of the hypothalamic-pituitary-adrenal (HPA) axis protect the brain from such disorders, and how in a different context these very same stress hormones may enhance vulnerability. This contribution focuses on the corticosteroids which exert through two distinct nuclear receptor types control over gene networks underlying stress system activity in brain. The mineralocorticoid receptor mediates the pro-active mode of corticosteroid action involved in maintenance of basal stress system activity. The glucocorticoid receptor mediates the reactive feedback mode aimed to facilitate recovery from stress-induced disturbance. The balance between these pro-active and reactive modes of control is thought to be of critical importance for homeostasis, and thus for control of hormone-responsive genes which enhance vulnerability to stress-related affective and neurodegenerative disorders. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Stress nationallicence adaptation nationallicence corticosteroids nationallicence brain nationallicence Stress nationallicence aanpassing nationallicence corticosteroiden nationallicence hersener nationallicence Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 11-14 0924-2708 11:1<11 1999 11 NEU https://doi.org/10.1017/S0924270800036292 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036292 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- de Kloet E.R. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 11-14 0924-2708 11:1<11 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge