caa a22 4500 388111208 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S0924270800036279 doi S0924270800036279 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036279 van den Brink W. Academisch Medisch Centrum, Universiteit van Amsterdam, divisie Psychiatric Amsterdam Institute for Addiction Research Dimensional models and neurobiology of personality disorders [Elektronische Daten] [W. van den Brink] Dimensionele benadering en neurobiologie van persoonlijkheidsstoornissen Since the introduction of a separate axis in DSM-III (1980), the validity of the categorical nature of the classification of personality disorders has been seriously questioned. Subsequently, a number of multidimensional alternatives have been proposed based on statistical procedures or theoretical considerations. At the same time, the study of the neurobiological underpinnings of personality and personality disorders has created a better understanding of etiological and pathogenetic processes responsible for these chronic disorders. The findings of these studies corroborate some of the major findings of statistical studies regarding the nature of the frequent comorbidity of axis II disorders. In the discussion, a mixed, two-tier diagnostic model is proposed to serve both scientific and clinical aims without the disadvantages of an exclusive choice for either categorical or dimensional approaches to the classification of personality pathology. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Personality disorder nationallicence classification nationallicence taxonomy nationallicence neurobiology nationallicence Persoonlijkheidsstoornis nationallicence classificatie nationallicence taxonomie nationallicence neurobiologie nationallicence Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 1-4 0924-2708 11:1<1 1999 11 NEU https://doi.org/10.1017/S0924270800036279 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036279 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- van den Brink W. Academisch Medisch Centrum, Universiteit van Amsterdam, divisie Psychiatric Amsterdam Institute for Addiction Research NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/1(1999-03), 1-4 0924-2708 11:1<1 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge