caa a22 4500 388111216 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0924270800036127 doi S0924270800036127 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036127 McGuffin P. Methodology of genetic research in psychiatry [Elektronische Daten] [P. McGuffin] Most forms of behaviour whether normal or abnormal, show a tendency to run in families. However, these can range from symptoms of dementia and movement disorder caused by the comparatively rare autosomal dominant Huntington's disease to common everyday aspects of behaviour such as religious persuasion or career choice. Normal behaviours and most common disorders do not show simple mendelian inheritance but instead have more complex patterns of transmission involving either major genes with incomplete penetrance, multiple genes of small effect, or a combination of the two. In addition, common complex phenotypes usually involve the combination of genetic and environmental factors. Therefore once family studies have shown that a disorder or trait is familial the next stage is to perform twin studies and, if possible adoption studies to investigate whether this results from shared genes, shared environment or a combination of the two. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Association gene mapping nationallicence genetic model fitting nationallicence linkage nationallicence Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 45-47 0924-2708 11:2<45 1999 11 NEU https://doi.org/10.1017/S0924270800036127 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036127 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- McGuffin P. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 45-47 0924-2708 11:2<45 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge