caa a22 4500 388111232 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0924270800036206 doi S0924270800036206 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036206 Molecular players in the development and maintenance of mesencephalic dopamine systems [Elektronische Daten] Several psychiatric diseases are considered to be neuro-developmental disorders. Amongst these are schizophrenia and autism, in which genetic and environmental components have been indicated. In these disorders intrinsic molecular mechanisms of brain development may be deranged due to genetic predispositions, or modified by external influences. Brain development is a delicate process of well-tuned cellular proliferation and differentiation of multipotent neural progenitor cells driven by spatiotemporal cues. One of the fundamental mechanisms is the interaction between external signals, e.g. growth factors, and internal regulators, e.g. transcription factors. An important transmitter system involved in behavioural and affective functions relevant for psychiatric disorders is the mesencephalic dopamine (DA) system. The mesencephalic DA system is organized in two anatomically and functionally different systems. DA neurons in the ventral tegmental area project to the mesolimbic system and are mostly related to control of behaviour. It has been implicated in drug addiction and affective disorders like dipolar disorder and schizophrenia. The dopamine system of the substantia nigra (nigro-striatal pathway) is implicated in movement control. Degeneration of this system, as in Parkinson's disease, or altered function in tardive dyskinesia have highlighted its importance in human disease. Recent findings in molecular neurobiology have provided the first clues to molecular mechanisms involved in developing and mature DA neurons. These may have clinical implications in novel therapeutic strategies. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Brain development nationallicence dopamine systems nationallicence embyonic brain nationallicence homeobox genes nationallicence transcription factors nationallicence Ptx3 nationallicence Burbach J.P.H. Cazorla P. Smidt M.P. Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 71-73 0924-2708 11:2<71 1999 11 NEU https://doi.org/10.1017/S0924270800036206 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036206 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burbach J.P.H. NATIONALLICENCE 700 1- Cazorla P. NATIONALLICENCE 700 1- Smidt M.P. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 71-73 0924-2708 11:2<71 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge