caa a22 4500 388111259 CHVBK 20180307125353.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0924270800036140 doi S0924270800036140 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036140 Searching for genes in Schizophrenia [Elektronische Daten] Decades of research into the etiology of schizophrenia on a phenotypic level, i.e. studies of neuroanatomy, neuropathology, neurophysiology and other areas such as immunology have yielded only fragmentary results. A contribution of genetic factors, has been consistently shown, however, beginning with E. Kraepelin's pioneering studies at the turn of the century. Evidence has accumulated from family-, twin-, and adoption studies. Identical twins have a 48% risk of developing schizophrenia if one of them is affected. In contrast, a 17 % risk is reported for nonidentical twins. These rates are similar to other complex genetic disorders such as diabetes, hypertension and asthma. Advances in the genetic analysis of complex traits as well as progress in the Human Genome Project should provide a basis for uncovering the molecular causes of schizophrenic disorders and for investigating the neuropathology of this individually and socially devastating neuropsychiatrie disorder. There is no doubt, that discovery of the genetic variation associated with the illness would help in identifying specific targets for development of more effective, targeted treatments. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Complex disorder nationallicence gene identification linkage nationallicence mapping nationallicence schizophrenia nationallicence susceptibility genes nationallicence Wildenauer D.B. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn Schwab S.G. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn Maier W. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn Lerer B. Dept. of Psychiatry, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 50-53 0924-2708 11:2<50 1999 11 NEU https://doi.org/10.1017/S0924270800036140 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036140 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wildenauer D.B. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn NATIONALLICENCE 700 1- Schwab S.G. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn NATIONALLICENCE 700 1- Maier W. Molecular Genetics Laboratory, Dept. of Psychiatry, University of Bonn NATIONALLICENCE 700 1- Lerer B. Dept. of Psychiatry, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 50-53 0924-2708 11:2<50 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge