caa a22 4500 388111313 CHVBK 20180307125354.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0924270800036164 doi S0924270800036164 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036164 Lesch K.P. Serotonergic gene variation: implications for personality traits and psychopathology [Elektronische Daten] [K.P. Lesch] Serotonin 5-hydroxytryptamine (5-HT) is an important regulator of morphogenetic activities during early central nervous system development, including cell proliferation, migration, and differentiation as well as synapto-genesis. Serotonergic raphe neurons diffusely project to a variety of brain regions (e.g. cortex, amygdala, hippocampus) and play known roles in integrating emotion, cognition, motor function as well as in food intake, sleep, pain, and sexual activity. The diversity of physiologic functions is due to the fact that 5-HT acts as a master control neurotransmitter within a highly complex system of neural communication mediated by multiple pre- and postsynaptic 5-HT receptors, thus orchestrating the activity and interaction of several other neurotransmitter systems. Since proteins involved in the regulation of central serotonergic activity (e.g. enzymes, receptors, transporter) play pivotal role in brain 5-HT homeostasis, polymorphisms in the regulatory regions of their genes resulting in variation of expression and function are likely to influence complex traits, such as temperament/personality and psychopathology. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Affective disorders nationallicence alcoholism anxiety disorders nationallicence genes nationallicence personality disorders nationallicence personality traits nationallicence polymorphisms nationallicence serotonin nationallicence Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 57-59 0924-2708 11:2<57 1999 11 NEU https://doi.org/10.1017/S0924270800036164 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036164 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lesch K.P. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 57-59 0924-2708 11:2<57 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge