caa a22 4500 388111364 CHVBK 20180307125354.0 cr unu---uuuuu 161130e199906 xx s 000 0 eng 10.1017/S0924270800036176 doi S0924270800036176 pii (NATIONALLICENCE)cambridge-10.1017/S0924270800036176 Genes for Alzheimer Dementia [Elektronische Daten] Alzheimer disease (AD), the most common form of dementia in the elderly, is rapidly becoming a major health problem in developed countries where the number of elderly people continuously grows due to improved medical care. Consequently, the number of AD patients is increasing and thus far no effective therapies are available. Clinically the disease can be diagnosed with 90% reliability on the basis of neurological examination, neuropsychological testing and brain imaging techniques. A definite diagnosis, however, requires the post-mortem detection of senile plaques (SPs) and neurofibrillary tangles (NFTs) in the brain. The SPs are extracellular deposits mainly composed of amyloid P (Ap) surrounded by dystrophic neurites. NFT are intraneural inclusions of paired helical filaments composed of hyperphosphorylated tau. Although age is the major risk factor for AD, population survey and family studies have provided substantial evidence that genetic factors are major contributors to the expression of AD. Copyright © Scandinavian College of Neuropsychopharmacology 1999 Amyloid precursor protein alzheimer disease nationallicence genetics nationallicence presenilins nationallicence Theuns J. Van Broeckhoven C. Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 60-62 0924-2708 11:2<60 1999 11 NEU https://doi.org/10.1017/S0924270800036176 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0924270800036176 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Theuns J. NATIONALLICENCE 700 1- Van Broeckhoven C. NATIONALLICENCE 773 0- Acta Neuropsychiatrica Cambridge University Press 11/2(1999-06), 60-62 0924-2708 11:2<60 1999 11 NEU CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge