caa a22 4500 388112468 CHVBK 20180307125357.0 cr unu---uuuuu 161130e199903 xx s 000 0 eng 10.1017/S0022149X99000372 doi S0022149X99000372 pii (NATIONALLICENCE)cambridge-10.1017/S0022149X99000372 Humoral immune responses induced by Gymnorhynchus gigas extracts in BALB/c mice [Elektronische Daten] The aim of this study was to determine if the plerocercoid larvae of Gymnorhynchus gigas, a common cestode of the ray's bream (Brama raii), possess antigenic compounds potentially capable of provoking anaphylactic episodes. A murine experimental model, using BALB/c mice, was developed to study the humoral immune response induced by G. gigas extracts. A highly specific humoral immune response was detected and cross-reactions were not observed between parasite and host antigens. The presence of IgM and IgG3 levels suggest the presence of thymus-independent antigens in the parasitic extract. The IgG antibody class showed the highest levels, with the IgG1 the predominant subclass. These IgG1 levels are in accordance with the supposed presence of a type I allergic reaction after the ingestion of G. gigas plerocercoids parasitizing fish, as well as inducing anaphylaxia in fish. These results indicate that somatic products released from ingested larvae of G. gigas could induce the development of a Th2 response capable of causing allergic disorders. Cambridge University Press Rodero M. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain Cuéllar C. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain Journal of Helminthology Cambridge University Press 73/3(1999-03), 239-243 0022-149X 73:3<239 1999 73 JHL https://doi.org/10.1017/S0022149X99000372 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022149X99000372 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rodero M. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain NATIONALLICENCE 700 1- Cuéllar C. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain NATIONALLICENCE 773 0- Journal of Helminthology Cambridge University Press 73/3(1999-03), 239-243 0022-149X 73:3<239 1999 73 JHL CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge