caa a22 4500 388112786 CHVBK 20180307125358.0 cr unu---uuuuu 161130e199904 xx s 000 0 eng 10.1017/S0022149X99000554 doi S0022149X99000554 pii (NATIONALLICENCE)cambridge-10.1017/S0022149X99000554 Nematocide activity of 6,7-diarylpteridines in three experimental models [Elektronische Daten] The in vitro nematocide activity of seventeen 6,7-diarylpteridines has been tested using three different experimental models, Caenorhabditis elegans, Nippostrongylus brasiliensis and Heligmosomoides polygyrus. The method of evaluation of inhibition in the secretion of acetylcholinesterase by H. polygyrus seems to be the most indicated to avoid false positives. The in vivo activities, against Trichinella spiralis, of the most in vitro active pteridines have been assayed. All pteridine derivatives bearing 6,7-di-p-bromophenyl substituents have shown in vitronematocide activites in the three experimental models used. Amongst all the pteridines tested in vivo, only 2,4-pteridinedithione derivatives exhibited moderate activity. Cambridge University Press Ochoa C. Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain Rodríguez M. Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain Domínguez L. Facultad de Química, Universidad de la República, Montevideo, Uruguay Saldaña J. Facultad de Química, Universidad de la República, Montevideo, Uruguay Di Maio R. Facultad de Química, Universidad de la República, Montevideo, Uruguay Alonso-Villalobos P. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain Martínez Grueiro M.M. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain Journal of Helminthology Cambridge University Press 73/4(1999-04), 333-336 0022-149X 73:4<333 1999 73 JHL https://doi.org/10.1017/S0022149X99000554 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022149X99000554 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ochoa C. Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain NATIONALLICENCE 700 1- Rodríguez M. Instituto de Química Médica (CSIC), Calle Juan de la Cierva 3, 28006, Madrid, Spain NATIONALLICENCE 700 1- Domínguez L. Facultad de Química, Universidad de la República, Montevideo, Uruguay NATIONALLICENCE 700 1- Saldaña J. Facultad de Química, Universidad de la República, Montevideo, Uruguay NATIONALLICENCE 700 1- Di Maio R. Facultad de Química, Universidad de la República, Montevideo, Uruguay NATIONALLICENCE 700 1- Alonso-Villalobos P. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain NATIONALLICENCE 700 1- Martínez Grueiro M.M. Departamento de Parasitología Facultad de Farmacia, Universidad Complutense, Madrid, Spain NATIONALLICENCE 773 0- Journal of Helminthology Cambridge University Press 73/4(1999-04), 333-336 0022-149X 73:4<333 1999 73 JHL CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge