caa a22 4500 388115297 CHVBK 20180307125405.0 cr unu---uuuuu 161130e199909 xx s 000 0 eng 10.1017/S1047951100005370 doi S1047951100005370 pii (NATIONALLICENCE)cambridge-10.1017/S1047951100005370 Reduced frequency of occlusion of aorto-pulmonary shunts in infants receiving Aspirin [Elektronische Daten] Abstract Objective Infants with severely reduced pulmonary perfusion due to complex congenital cardiac malformations are in need of an improved flow of blood to the lungs. One option for treatment is to construct a systemic-to-pulmonary arterial shunt. Although such shunts have been used since 1945, their spontaneous occlusion remains a major problem in the long-term. Design We studied all infants in whom a systemic-to-pulmonary arterial shunt had been constructed using a Gore-Tex tube graft between December 1989 and March 1996. Patients Of 46 infants undergoing construction of a shunt, 7 (15°) died within 30 days of surgery. The shunts had to be taken down in 2 infants. Thus, 37 infants were included in the study. All but three infants received Aspirin. Aspirin was discontinued on the personal decision of individual physicians. Of 22 infants, 3 never received Aspirin, and in 19 it was stopped well before undertaking subsequent surgery. Aspirin was administered continuously to 15 infants until further surgery. Results Those in whom Aspirin was discontinued, or not given, and those receiving Aspirin until further surgery, were comparable concerning their age, time of follow-up, severity of the cardiac lesions, and size and type of shunt. Partial or complete occlusion of the shunt occurred in 2 of 15 (13°) infants taking Aspirin, but was seen in 12 of 22 (54°) infants in whom Aspirin was discontinued. Of these, 3 died due to acute occlusion of the shunt. Conclusions Aspirin reduced effectively the rate of occlusion of systemic-to-pulmonary arterial shunts, and should be continued as long as the shunt is in place. Copyright © Cambridge University Press 1999 Aspirin nationallicence aorto-pulmonary shunt nationallicence occlusion nationallicence infancy nationallicence Motz Reinald Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany Wessel Armin Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany Ruschewski Wofgang Clinic of Paediatric Cardio-thoracic Surgery, Georg-August-University, Göttingen, Germany Bürsch Jochen Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany Cardiology in the Young Cambridge University Press 9/5(1999-09), 474-477 1047-9511 9:5<474 1999 9 CTY https://doi.org/10.1017/S1047951100005370 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1047951100005370 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Motz Reinald Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany NATIONALLICENCE 700 1- Wessel Armin Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany NATIONALLICENCE 700 1- Ruschewski Wofgang Clinic of Paediatric Cardio-thoracic Surgery, Georg-August-University, Göttingen, Germany NATIONALLICENCE 700 1- Bürsch Jochen Clinic for Paediatric Cardiology, Georg-August-University, Göttingen, Germany NATIONALLICENCE 773 0- Cardiology in the Young Cambridge University Press 9/5(1999-09), 474-477 1047-9511 9:5<474 1999 9 CTY CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge