cad a22 4500 390147990 20181103044322.0 cr unu---uuuuu 161201e20021219xx s 000 0 eng 10.5167/uzh-128322 doi 10.1016/S0264-410X(02)00389-4 doi (ZORA)oai:www.zora.uzh.ch:128322 570 ddc 630 ddc 12477430 pmid Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV [Elektronische Daten] [Flavia Ferrantelli, Robert A Rasmussen, Regina Hofmann-Lehmann, Weidong Xu, Harold M McClure, Ruth M Ruprecht] restrictedAccess eu-repo Successes for neutralizing antibodies (nAbs) against the human immunodeficiency virus (HIV) include potent cross-clade neutralization of primary virus isolates by human neutralizing monoclonal antibodies (nmAbs) targeting conserved envelope epitopes. Furthermore, passively administered combinations of human nmAbs prevented infection in primates, indicating that epitopes recognized by such nmAbs are key determinants for protection. Lastly, in the absence of CD8+ T cells, nAbs may act as a second line of defense during chronic infection. Taken together, these results argue for generating nAb response-based prophylactic and/or therapeutic AIDS vaccines. We suggest that the epitopes identified by passive immunization represent excellent targets for the rational design of nAb response-based AIDS vaccines. Department of Farm Animals zora Ferrantelli Flavia joint author Rasmussen Robert A. joint author Hofmann-Lehmann Regina joint author Xu Weidong joint author McClure Harold M. joint author Ruprecht Ruth M. joint author Vaccine 20(Suppl 4):A61-A65 https://www.zora.uzh.ch/id/eprint/128322/1/Ferrantelli%20Do.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/128322/1/Ferrantelli%20Do.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Ferrantelli Flavia joint author ZORA 700 1- Rasmussen Robert A. joint author ZORA 700 1- Hofmann-Lehmann Regina joint author ZORA 700 1- Xu Weidong joint author ZORA 700 1- McClure Harold M. joint author ZORA 700 1- Ruprecht Ruth M. joint author ZORA 773 0- Vaccine 20(Suppl 4):A61-A65 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article restrictedAccess