cad a22 4500 390148008 20181103044323.0 cr unu---uuuuu 161201e20020506xx s 000 0 eng 10.5167/uzh-128323 doi 10.1016/S0264-410X(02)00077-4 doi (ZORA)oai:www.zora.uzh.ch:128323 570 ddc 630 ddc 11983253 pmid Passive immunization with human neutralizing monoclonal antibodies: correlates of protective immunity against HIV [Elektronische Daten] [Weidong Xu, Regina Hofmann-Lehmann, Harold M McClure, Ruth M Ruprecht] restrictedAccess eu-repo Passive immunization with synergistic combinations of human monoclonal antibodies (mAbs) directed against conserved epitopes of the human immunodeficiency virus (HIV) envelope completely protected 13 out of 16 rhesus monkeys challenged intravenously or orally with chimeric simian-human immunodeficiency virus (SHIV) strains; partial protection was seen in another two. A high degree of protection was seen among orally challenged neonates. Thus, we propose that passive immunization with synergistic combinations of neutralizing human mAbs may be effective in preventing maternal HIV transmission when given as post-exposure prophylaxis at birth and as prophylaxis against milk-borne transmission. Because we only used mAbs with well-defined epitope specificities, our studies also yield key information for designing AIDS vaccines: the correlates of immune protection. Vaccine strategies that can evoke antibody responses to epitopes recognized by the mAbs used in our primate studies could be important components of successful AIDS vaccines. Department of Farm Animals zora Xu Weidong joint author Hofmann-Lehmann Regina joint author McClure Harold M. joint author Ruprecht Ruth M. joint author Vaccine 20(15):1956-1960 https://www.zora.uzh.ch/id/eprint/128323/1/Xu%20Passive.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/128323/1/Xu%20Passive.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Xu Weidong joint author ZORA 700 1- Hofmann-Lehmann Regina joint author ZORA 700 1- McClure Harold M. joint author ZORA 700 1- Ruprecht Ruth M. joint author ZORA 773 0- Vaccine 20(15):1956-1960 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article restrictedAccess