cad a22 4500 390148016 20181103044323.0 cr unu---uuuuu 161201e200206 xx s 000 0 eng 10.5167/uzh-128324 doi 10.1034/j.1600-0684.2002.01014.x doi (ZORA)oai:www.zora.uzh.ch:128324 570 ddc 630 ddc 12190851 pmid Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge [Elektronische Daten] [Regina Hofmann-Lehmann, J Vlasak, R A Rasmussen, S Jiang, P L Li, T W Baba, D C Montefiori, B J Bernacky, T A Rizvi, R Schmidt, L R Hill, M E Keeling, H Katinger, G Stiegler, L A Cavacini, M R Posner, Ruth M Ruprecht] restrictedAccess eu-repo Simian-human immunodeficiency viruses (SHIV) allow the evaluation of antiviral strategies that target the envelope glycoproteins of the human immunodeficiency virus 1 (HIV-1) in macaques. We previously protected neonates from oral challenge with cell-free SHIV-vpu+ by passive immunization with synergistic human neutralizing monoclonal antibodies (mAbs) (Baba et al., Nat Med 6:200-206, 2000). mAbs were administered prenatally to pregnant dams and postnatally to the neonates. Here, we used solely postnatal or postexposure mAb treatment, thus significantly reducing the amount of mAbs necessary. All neonatal monkeys were also protected with these abbreviated mAb regimens. Our results are directly relevant for humans because we used mAbs that target HIV-1 envelope glycoproteins. Thus, the large-scale use of passive immunization with neutralizing mAbs may be feasible in human neonates. The mAbs, being natural human proteins, can be expected to have low toxicity. Passive immunization has promise to prevent intrapartum as well as milk-borne virus transmission from HIV-1-infected women to their infants. Department of Farm Animals zora Hofmann-Lehmann Regina joint author Vlasak J. joint author Rasmussen R A. joint author Jiang S. joint author Li P L. joint author Baba T W. joint author Montefiori D C. joint author Bernacky B J. joint author Rizvi T A. joint author Schmidt R. joint author Hill L R. joint author Keeling M E. joint author Katinger H. joint author Stiegler G. joint author Cavacini L A. joint author Posner M R. joint author Ruprecht Ruth M. joint author Journal of Medical Primatology 31(3):109-119 https://www.zora.uzh.ch/id/eprint/128324/1/Postnatal.pdf text/html WWW-Backlink auf das Repository 1 Journal Article PeerReviewed zora ZORA 856 40 https://www.zora.uzh.ch/id/eprint/128324/1/Postnatal.pdf text/html WWW-Backlink auf das Repository ZORA 700 1- Hofmann-Lehmann Regina joint author ZORA 700 1- Vlasak J. joint author ZORA 700 1- Rasmussen R A. joint author ZORA 700 1- Jiang S. joint author ZORA 700 1- Li P L. joint author ZORA 700 1- Baba T W. joint author ZORA 700 1- Montefiori D C. joint author ZORA 700 1- Bernacky B J. joint author ZORA 700 1- Rizvi T A. joint author ZORA 700 1- Schmidt R. joint author ZORA 700 1- Hill L R. joint author ZORA 700 1- Keeling M E. joint author ZORA 700 1- Katinger H. joint author ZORA 700 1- Stiegler G. joint author ZORA 700 1- Cavacini L A. joint author ZORA 700 1- Posner M R. joint author ZORA 700 1- Ruprecht Ruth M. joint author ZORA 773 0- Journal of Medical Primatology 31(3):109-119 BK010053 XK010053 XK010000 ZORA ZORA ZORA Journal Article restrictedAccess