Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques
| LEADER | cad a22 4500 | ||
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| 001 | 390148059 | ||
| 005 | 20181103044323.0 | ||
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| 008 | 161201e20020412xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.5167/uzh-128336 |2 doi |
| 024 | 7 | 0 | |a 10.1097/00002030-200204120-00002 |2 doi |
| 035 | |a (ZORA)oai:www.zora.uzh.ch:128336 | ||
| 084 | |a 570 |2 ddc | ||
| 084 | |a 630 |2 ddc | ||
| 091 | |a 11919484 |b pmid | ||
| 245 | 0 | 0 | |a Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques |h [Elektronische Daten] |c [Robert A Rasmussen, Regina Hofmann-Lehmann, Pei-Lin Li, Josef Vlasak, Joern E Schmitz, Keith A Reimann, Marcelo J Kuroda, Norman L Letvin, David C Montefiori, Harold M McClure, Ruth M Ruprecht] |
| 506 | |a closedAccess |2 eu-repo | ||
| 520 | 3 | |a OBJECTIVE: To directly examine the role of CD8+ T cells in controlling viremia and disease during chronic, low-level primate immunodeficiency virus infection in DNA prime/protein boost-vaccinated macaques. BACKGROUND: A cohort of macaques, vaccinated with either a DNA prime/HIV-1 gp160 boost regimen or with gp160 alone was previously protected partially from sequential challenges with non-pathogenic and pathogenic strains of chimeric simian/human immunodeficiency virus (SHIV). In this study, the effect of temporary ablation of CD8+ T cells in these animals was examined. METHODS: Animals were treated with an anti-CD8 antibody and CD8+ T-cell levels in peripheral blood, plasma viral loads, peripheral blood mononuclear cell-associated virus levels, neutralizing antibody (nAb) titers and simian immunodeficiency virus Gag-specific CD8+ T-cell numbers were followed. RESULTS: Plasma viremia rose sharply in direct synchrony with a rapid but transient drop in CD8+ T cells. However, although levels of cell-associated virus also rose concomitantly, peak levels were much lower than those in virus-challenged, naive animals. In addition, despite a rise of pathogenic SHIV89.6P RNA levels in three animals, CD4+ T-cell counts remained unchanged. In each of these animals, neutralizing antibody titers against the pathogenic SHIV89.6P strain were high. CONCLUSIONS: The results indicate that CD8+ T cells play a key role in suppressing viremia in a chronically infected host. In addition, the results suggest that in the absence of CD8+ T cells, nAb may act as an effective second line of defense by limiting both the spread of infectious virus to new target cells and CD4+ T-cell loss. | |
| 690 | 7 | |a Department of Farm Animals |2 zora | |
| 700 | 1 | |a Rasmussen |D Robert A. |e joint author | |
| 700 | 1 | |a Hofmann-Lehmann |D Regina |e joint author | |
| 700 | 1 | |a Li |D Pei-Lin |e joint author | |
| 700 | 1 | |a Vlasak |D Josef |e joint author | |
| 700 | 1 | |a Schmitz |D Joern E. |e joint author | |
| 700 | 1 | |a Reimann |D Keith A. |e joint author | |
| 700 | 1 | |a Kuroda |D Marcelo J. |e joint author | |
| 700 | 1 | |a Letvin |D Norman L. |e joint author | |
| 700 | 1 | |a Montefiori |D David C. |e joint author | |
| 700 | 1 | |a McClure |D Harold M. |e joint author | |
| 700 | 1 | |a Ruprecht |D Ruth M. |e joint author | |
| 773 | 0 | |t AIDS |g 16(6):829-838 | |
| 856 | 4 | 0 | |u https://www.zora.uzh.ch/id/eprint/128336/1/Neutralizing_antibodies_as_a_potential_secondary.2.pdf |q text/html |z WWW-Backlink auf das Repository |
| 908 | |D 1 |a Journal Article |z PeerReviewed |2 zora | ||
| 950 | |B ZORA |P 856 |E 40 |u https://www.zora.uzh.ch/id/eprint/128336/1/Neutralizing_antibodies_as_a_potential_secondary.2.pdf |q text/html |z WWW-Backlink auf das Repository | ||
| 950 | |B ZORA |P 700 |E 1- |a Rasmussen |D Robert A. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Hofmann-Lehmann |D Regina |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Li |D Pei-Lin |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Vlasak |D Josef |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Schmitz |D Joern E. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Reimann |D Keith A. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Kuroda |D Marcelo J. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Letvin |D Norman L. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Montefiori |D David C. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a McClure |D Harold M. |e joint author | ||
| 950 | |B ZORA |P 700 |E 1- |a Ruprecht |D Ruth M. |e joint author | ||
| 950 | |B ZORA |P 773 |E 0- |t AIDS |g 16(6):829-838 | ||
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 949 | |B ZORA |F ZORA |b ZORA |j Journal Article |c closedAccess | ||