caa a22 4500 397493932 CHVBK 20180308164516.0 cr unu---uuuuu 161202e199501 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a124695 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a124695 Geranylgeraniol Is a Potent Inducer of Apoptosis in Tumor Cells [Elektronische Daten] [Hidekazu Ohizumi, Yutaka Masuda, Shigeo Nakajo, Itaru Sakai, Shigemitsu Ohsawa, Kazuyasu Nakaya] We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM. © 1995 BY THE JOURNAL OF BIOCHEMISTRY Rapid Communication nationallicence apoptosis nationallicence geranylgeraniol nationallicence isoprenoid nationallicence tumor cell nationallicence Ohizumi Hidekazu School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut Masuda Yutaka School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut Nakajo Shigeo School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut Sakai Itaru Products Formulation Research Laboratory, Eisai Co., Ltd. 2-3-14 Minami, Honjo, Saitama 367 aut Ohsawa Shigemitsu Products Formulation Research Laboratory, Eisai Co., Ltd. 2-3-14 Minami, Honjo, Saitama 367 aut Nakaya Kazuyasu School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut The Journal of Biochemistry Oxford University Press 117/1(1995-01), 11-13 0021-924X 117:1<11 1995 117 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a124695 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a124695 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ohizumi Hidekazu School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut NATIONALLICENCE 700 1- Masuda Yutaka School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut NATIONALLICENCE 700 1- Nakajo Shigeo School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut NATIONALLICENCE 700 1- Sakai Itaru Products Formulation Research Laboratory, Eisai Co., Ltd. 2-3-14 Minami, Honjo, Saitama 367 aut NATIONALLICENCE 700 1- Ohsawa Shigemitsu Products Formulation Research Laboratory, Eisai Co., Ltd. 2-3-14 Minami, Honjo, Saitama 367 aut NATIONALLICENCE 700 1- Nakaya Kazuyasu School of Pharmaceutical Sciences, Showa University 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 117/1(1995-01), 11-13 0021-924X 117:1<11 1995 117 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford