caa a22 4500 397494068 CHVBK 20180308164516.0 cr unu---uuuuu 161202e199503 xx s 000 0 eng 10.1093/oxfordjournals.jbchem.a124758 doi (NATIONALLICENCE)oxford-10.1093/oxfordjournals.jbchem.a124758 Distinct Effects of Saturated Fatty Acids on Protein Kinase C Subspecies [Elektronische Daten] [Koichi Kasahara, Ushio Kikkawa] The effects of saturated fatty acids on the protein kinase C family were studied. Saturated fatty acids with carbon chain lengths of C12 to C14 activated the α-, β-, γ, and є-subspecies, and this activation was synergistic with that by diacylglycerol. Tridecanoic acid (C13) was most effective among the saturated fatty acids examined. Saturated fatty acids having carbon chain lengths of less than C10 were inert, and fatty acids with longer carbon chain lengths, such as C16 and C18, showed little effect. In contrast, fatty acids were almost inactive toward the δ-subspecies, and rather inhibited its activity in the presence of phosphatidyl-serine and diacylglycerol. Phorbol ester enhanced the activity of the α-, β-, and γ-subspecies when added with fatty acids; however, it suppressed the activity of the є -subspecies in the presence of fatty acids. Saturated fatty acids having different effects on protein kinase C subspecies may be useful as tools for studying the mechanism and role of protein kinase C activation. © 1995 BY THE JOURNAL OF BIOCHEMISTRY Regular Papers nationallicence diacylglycerol nationallicence fatty acid nationallicence phorbol ester nationallicence phospholipid nationallicence protein kinase C nationallicence Kasahara Koichi Department of Biochemistry, Kobe University School of Medicine Chuo-ku, Kobe, Hyogo 650 aut Kikkawa Ushio Biosignal Research Center, Kobe University Nada-ku, Kobe, Hyogo 657 aut The Journal of Biochemistry Oxford University Press 117/3(1995-03), 648-653 0021-924X 117:3<648 1995 117 jbchem https://doi.org/10.1093/oxfordjournals.jbchem.a124758 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/oxfordjournals.jbchem.a124758 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kasahara Koichi Department of Biochemistry, Kobe University School of Medicine Chuo-ku, Kobe, Hyogo 650 aut NATIONALLICENCE 700 1- Kikkawa Ushio Biosignal Research Center, Kobe University Nada-ku, Kobe, Hyogo 657 aut NATIONALLICENCE 773 0- The Journal of Biochemistry Oxford University Press 117/3(1995-03), 648-653 0021-924X 117:3<648 1995 117 jbchem Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford