caa a22 4500 397495250 CHVBK 20180308164519.0 cr unu---uuuuu 161202e199511 xx s 000 0 eng 10.1016/S1010-7940(05)80110-1 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80110-1 Residual cognitive dysfunctioning at 6 months following coronary artery bypass graft surgery [Elektronische Daten] Neuropsychological testing is a sensitive method for quantitativeassessment of cognitive dysfunctioning following cardiopulmonary bypass(CPB). However, the methodological problems associated with this method,such as learning effects due to repeated testing and the effects ofdistress on test performance, have often been underestimated. In thisstudy, these confounding effects were controlled for by including thespouses of patients, exposed to the same potential stress effectsassociated with the operation, as a nonsurgical control group. Theexperimental group consisted of 63 patients (40-75 years) undergoingelective coronary artery bypass graft (CABG) surgery. A battery ofstandardized neuropsychological tests was administered to both groups 2weeks preoperatively and 1 week, 1 month, and 6 months postoperatively.Statistical testing of inter-group differences in preoperative topostoperative changes in test performance revealed the following results:(1) For immediate memory and learning, in general test scores showed thesame time course for both groups. (2) For recent memory, patients' scoresshowed a significant deterioration at 1 month after CABG surgery comparedwith the scores of spouses. This effect had not completely disappeared at 6months postoperatively. (3) For attention and psychomotor speed as well asverbal fluency, patients' scores had deteriorated significantly at 1 weekafter surgery, with incomplete recovery at 6 months. These negativecognitive effects were not related to the patients' ages or CPB parameters(duration of CPB, aortic cross-clamp time, mean flow and arterial pressureduring CPB and aortic cross-clamping, and minimum nasopharyngealtemperature). No differences in self-ratings of mood over time were foundbetween the patients and spouses. The results indicate that, whenadequately controlling for the effects of learning and distress, somecognitive functions are still impaired at 6 months after CABG surgery. © Springer-Verlag European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/11(1995-11), 636-643 1010-7940 9:11<636 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80110-1 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80110-1 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/11(1995-11), 636-643 1010-7940 9:11<636 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford