caa a22 4500 397495366 CHVBK 20180308164519.0 cr unu---uuuuu 161202e199505 xx s 000 0 eng 10.1016/S1010-7940(05)80156-3 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80156-3 Altered regulation of breathing after bilateral lung transplantation [Elektronische Daten] In our previous animal studies on dogs, regulation of breathing wasfound to be altered after en bloc transplantation of the heart and bothlungs. During carbon dioxide (CO2) inhalation the minute volume wasincreased due to an increase of tidal volume after transplantation whereasbefore transplantation both respiratory frequency and tidal volumeincreased. The success of the heart-lung transplantation was based onexperiments on baboons as no long-term survivors were obtained in dogs. Itwas thought that the regulation of breathing is different in dogs andprimates. We therefore decided to study the regulation of breathing inhumans after bilateral lung transplantation during CO2 stimulation. Theregulation of breathing was tested 2 to 4 months after bilateral lungtransplantation in six patients. Six healthy subjects with intact lungswere tested as controls. The test persons were allowed to breathe firstroom air, then 5% CO2 in air for 4 min and then room air again. Thefrequency of respiration, tidal volume and minute ventilation were recordedusing a phneumotachograph. Simultaneously samples of arterial blood weredrawn from a cannulated brachial artery for analysis of pressure ofarterial oxygen (PaO2), pressure of arterial carbon dioxide (PaCO2), baseexcess (BE) and pH. During inhalation of CO2 for 4 min the minute volumedoubled in both transplant patients and in controls. The tidal volume ofthe transplant patients increased significantly more than that of thecontrols (P < 0.005) whereas respiratory frequency increasedsignificantly only in the controls with intact lungs (P <0.05).(ABSTRACT TRUNCATED AT 250 WORDS) European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/5(1995-05), 237-241 1010-7940 9:5<237 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80156-3 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80156-3 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/5(1995-05), 237-241 1010-7940 9:5<237 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford