caa a22 4500 397495382 CHVBK 20180308164519.0 cr unu---uuuuu 161202e199505 xx s 000 0 eng 10.1016/S1010-7940(05)80161-7 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80161-7 Circulating endothelin in patients undergoing coronary artery bypass grafting [Elektronische Daten] Increased synthesis of endothelin, (a powerful physiologicalvasoconstrictor), is a uniform response to endothelial injury and has beenassociated with myocardial ischemia and reperfusion. This study tests thehypothesis that coronary artery bypass grafting (CABG) affects endothelinplasma concentrations in various vascular beds. Twenty-four CABG patientswere included in this study. Endothelin was determined in multiple plasmaspecimens obtained from superior vena cava, aortic root and coronary sinus(CS). Venous endothelin plasma concentrations collected in CABG patientsbefore surgery were 1.16 +/- 0.18 pg/ml. They increased after sternotomy(1.71 +/- 0.12 pg/ml) and during (2.97 +/- 0.27 pg/ml) and aftercardiopulmonary bypass (CPB, 2.72 +/- 0.21 pg/ml). There is no net releaseof endothelin from the coronary circulation before (aorta 2.26 +/- 0.13pg/ml vs CS 2.44 +/- 0.17 pg/ml, not significant (n.s.), during(cardioplegia 2.55 +/- 0.17 pg/ml vs CS 2.45 +/- 0.15 pg/ml, n.s.), andafter aortic cross-clamping (aorta 2.95 +/- 0.23 pg/ml vs coronary sinus2.71 +/- 0.18 pg/ml, n.s.). Pulmonary endothelin clearance is preserved onpartial bypass (aorta 2.26 +/- 0.13 pg/ml vs vena cava 2.86 +/- 0.18 pg/ml,P < 0.003), but remains inhibited even 10-30 min after release of theaortic cross-clamp (aorta 2.95 +/- 0.23 pg/ml vs vena cava 2.97 +/- 0.27pg/ml, n.s.). Two out of 24 patients had severe myocardial ischemia. Thesepatients showed particularly high endothelin concentrations.(ABSTRACTTRUNCATED AT 250 WORDS) European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/5(1995-05), 269-274 1010-7940 9:5<269 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80161-7 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80161-7 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/5(1995-05), 269-274 1010-7940 9:5<269 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford