caa a22 4500 397495994 CHVBK 20180308164521.0 cr unu---uuuuu 161202e199510 xx s 000 0 eng 10.1016/S1010-7940(05)80003-X doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80003-X Improved 20-hour canine lung preservation with a new solution--ET-Kyoto solution [Elektronische Daten] We developed a new solution, ET-Kyoto (ET-K) solution, and compared itsefficacy in 20 h lung preservation with that of Euro-Collins (EC) solutionin a canine left lung transplantation model. The lungs were flushed withET-K solution (ET-K group, n = 5), with EC solution plus prostaglandin E1(PGE1) pretreatment (EC + PGE1 group, n = 6) or with EC solution (EC group,n = 6), and were stored at 4 degrees C for 20 h. The function of left lunggrafts was assessed 40, 70, and 130 min after transplantation. The arterialpressure of oxygen (PaO2) in the ET-K group was significantly greater thanin the EC + PGE1 group (p < 0.05 or p < 0.01) and in the EC group (p< 0.01). The peak inspiratory pressure and wet to dry weight ratio inthe ET-K group were significantly lower than in the EC + PGE1 group and inthe EC group (p < 0.05 or p < 0.01). Pulmonary vascular resistance inthe ET-K group 130 min after reperfusion was significantly lower than inthe EC group (p < 0.05). All the transplanted lungs in the EC + PGE1group and the EC group showed histological evidence of pulmonary edema,whereas all in the ET-K group showed no signs of edema. We concluded thatET-K solution is superior to EC solution with or without PGE1 pretreatmentin 20 h canine lung preservation. © Springer-Verlag European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/10(1995-10), 548-552 1010-7940 9:10<548 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80003-X text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80003-X text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/10(1995-10), 548-552 1010-7940 9:10<548 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford