caa a22 4500 397496036 CHVBK 20180308164521.0 cr unu---uuuuu 161202e199510 xx s 000 0 eng 10.1016/S1010-7940(05)80011-9 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80011-9 Intravenous amiodarone vs propafenone for atrial fibrillation and flutter after cardiac operation [Elektronische Daten] The safety and efficacy of amiodarone and propafenone in convertingatrial fibrillation or flutter after cardiac surgery were compared in arandomized double-blind trial. Eighty-four patients with sustained atrialtachyarrhythmias of more than 30 min' duration, stable hemodynamic statusand neither preoperative atrial arrhythmias nor treatment with otherantiarrhythmis drugs, were randomized to receive amiodarone (46 patients: 5mg/kg over 15 min and then 15 mg/kg over the subsequent 24 h fornon-converting) or propafenone (38 patients: 2 mg/kg over 15 in and then 10mg/kg over the subsequent 24 h for non- converting). Nine of the 46patients (19.5%) receiving amiodarone converted to sinus rhythm within 1 hfollowing bolus injection compared with 17 of 38 patients (44.7%) treatedwith propafenone (P < 0.05). Within the 24 h study, 38 of 46 patients(82.6%) given amiodarone and 26 of 38 patients (68.4%) given propafenonewere converted to sinus rhythm (P = NS). A significantly progressivereduction in ventricular response, already evident at 10th min from thestart of treatment, was achieved in both groups of patients. Side effectsoccurred in six patients given propafenone (15.7%) and in five givenamiodarone (10.8%) (P = NS). The two drugs were equally effective inconverting postoperative atrial fibrillation and/or flutter after 24 halthough propafenone was superior within the first hour. © Springer-Verlag European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/10(1995-10), 587-591 1010-7940 9:10<587 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80011-9 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80011-9 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/10(1995-10), 587-591 1010-7940 9:10<587 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford