caa a22 4500 397496079 CHVBK 20180308164521.0 cr unu---uuuuu 161202e199506 xx s 000 0 eng 10.1016/S1010-7940(05)80191-5 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80191-5 Prophylaxis in cardiac surgery. A controlled randomized comparison between cefazolin and cefuroxime [Elektronische Daten] In a prospective randomized two center trial, short-term prophylaxiswith cefuroxime (CFX) in 189 patients was compared with cefazolin (CFZ) in196 patients submitted to elective cardiac surgery. A total of 3 g wasadministered over 24 h in both groups. One major adverse reaction with CFXwas noted. Patients were prospectively screened by infectious diseasenurses for surgical wound and secondary infections. Sternal woundinfections occurred in eight patients treated with CFX and all were minor.One patient from this group eventually died of infectious causes. In theCFZ-treated patients two major and six minor wound infections occurredrequiring extensive debridement in two. Secondary infections occurred lessfrequently in the CFX group (13.2 per 100) than in the CFZ group (16.8 per100) with two infection-related deaths in the CFX and one in the CFZ group.The most commonly identified organisms were Staphylococcus aureus and avariety of gram-negative organisms. No major differences were observedbetween the CFX and CFZ groups. Short-term administration of 3 g CFZ or CFXin this study could not demonstrate the advantage of one of the antibioticsused over the other in terms of clinical outcome, incidence or site ofinfection or organisms identified. The 24 h administration of 3 g CFZ orCFX provided suboptimal prophylaxis for wound infection or secondaryinfections in patients undergoing elective open heart surgery. European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/6(1995-06), 325-329 1010-7940 9:6<325 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80191-5 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80191-5 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/6(1995-06), 325-329 1010-7940 9:6<325 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford