caa a22 4500 397496125 CHVBK 20180308164521.0 cr unu---uuuuu 161202e199506 xx s 000 0 eng 10.1016/S1010-7940(05)80187-3 doi (NATIONALLICENCE)oxford-10.1016/S1010-7940(05)80187-3 Preoperative chemotherapy and immunochemotherapy for locally advanced stage IIIA and IIIB non small cell lung cancer. Preliminary results [Elektronische Daten] From January 1991 to November 1993, 110 patients with histologicallyconfirmed stage IIIA and IIIB non-small cell lung cancer (NSCLC), were seenat our Institution. Our study was designed to evaluate whether redirectionto surgery of otherwise unresectable patients may be obtained bypreoperative therapy. Forty-nine patients were considered eligible forneoadjuvant treatment. Thirty-two (Group I) were treated with two or threecycles of cisplatin, vinblastine and mitomycin C and 17 (Group II) receivedtwo cycles of cisplatin, VP16, alpha 1 timosine and interferon. The overallresponse rate was 81.2% for Group I and 88.7% for Group II. Downstaging waspredictive of resectability (P < 0.05). Forty-one patients (83.6%)underwent thoracotomy with 37 (75.5%) radical resections. Conservativetechniques (bronchovascular reconstruction) (22 cases) were preferred overpneumonectomy (2 cases). The resectability rate was 84% for Group I and 87%for Group II (P = NS). Treatment-related complications were minor, with nodeaths. Postoperative complications occurred in two cases in each group(7.4% and 14.3%). There was no histologic evidence of tumor in threepatients. Two-year survival was 75% for Group I and 55% for Group II (P =NS). To date 35 patients who had complete resection are alive, and free ofdisease. We conclude that preoperative chemotherapy produces high responseand resectability rates in both stage IIIA and IIIB unresectable NSCLC;radical resection using a conservative technique is possible in patientswho are otherwise unresectable; no local recurrence occurred after radicalresection; no significant differences were demonstrated between the twoprotocols. European Journal of Cardio-Thoracic Surgery Elsevier Science B.V. 9/6(1995-06), 305-309 1010-7940 9:6<305 1995 9 ejcts https://doi.org/10.1016/S1010-7940(05)80187-3 text/html Onlinezugriff via DOI 1 abstract jats NATIONALLICENCE 856 40 https://doi.org/10.1016/S1010-7940(05)80187-3 text/html Onlinezugriff via DOI NATIONALLICENCE 773 0- European Journal of Cardio-Thoracic Surgery Elsevier Science B.V 9/6(1995-06), 305-309 1010-7940 9:6<305 1995 9 ejcts Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford